A Milestone in Ultrasound Contrast History:

04 April, 2016  First Approval by U.S. Food and Drug Administration for Contrast Enhanced Ultrasonography of the Liver Received by Bracco Diagnostics Inc. for LUMASON® (sulfur hexafluoride lipid-type A microspheres) for injectable suspension, for intravenous use.   LUMASON® has been approved for use in ultrasonography of the liver for characterization of focal liver lesions in adult and pediatric patients.


WFUMB International Guidelines for Contrast Enhanced Ultrasound

International guidelines for contrast-enhanced ultrasonography - ultrasound imaging in the new millennium - Ultrasonography 2016; 35(2): 89-103

Welcome to the SonoWorld Contrast-Enhanced Ultrasound Minisite

Here you will find a wide range of resources to help you learn about Contrast-Enhanced Ultrasound (CEUS), microbubbles, blood flow assessment, clinical utility of CEUS and many other topics related to the rapidly expanding field of Contrast-Enhanced Ultrasound.

What IS Contrast-Enhanced Ultrasound (CEUS)

Current CEUS agents are based on gas-filled microbubbles that are strongly reflective of ultrasound. When a bolus of microbubble contrast agent is injected intravenously it circulates through the body and greatly enhances acoustic backscatter from the blood wherever the agent is present. Contrast-Enhanced Ulrtrasound (CEUS) enhances the ability of conventional ultrasound imaging to detect and assess blood flow within the vascular system, organs and lesions.

Because Contrast-Enhanced Ultrasound does not involve use of ionizing radiation, there is increasing interest for its use in the pediatric population and for monitoring disease states over time where frequent re-examination is required.

Although Contrast-Enhanced Ultrasound is approved in the United States for only heart chamber opacification and for focal liver lesion characterization, it is used for an ever-increasing range of applications in other countries. In Europe it has become most widely used for evaluating liver lesions and in evaluations of the vascular system. Research continues on use of CEUS for assessment of organ perfusion.

There is also great interest in the use of ultrasound contrast agents as carriers of therapeutic agents such as genetic materials or chemotherapeutic materials. Conventional ultrasound imaging systems can be modified to image contrast agents at low power, and to destroy the bubbles by using higher power ultrasound to induce bubble collapse, releasing the attached therapeutic material precisely where needed.

Here in the SonoWorld Contrast-Enhanced Ultrasound minisite we will assemble educational resources to help you learn about Contrast-Enhanced Ultrasound, and explore the clinical applications that have been developed world-wide for this new diagnostic tool. You will find lectures on contrast enhanced ultrasound, cases that utilize CEUS to reach or enhance the diagnosis, Articles on Contrast-Enhanced Ultrasound, and News Stories related to ultrasound contrast agents.

Contrast-Enhanced Ultrasound (CEUS) also sometimes referred to as "Ultrasound Contrast" is the use of a natural or manufactured material that produces strong reflections of ultrasound waves, that can be injected into the body, enhancing the reflectance of ultrasound during ultrasound imaging.

What’s a Minisite?

Everything on this minisite is focused on contrast agents or related in some way to contrast agents. The content includes lectures, news stories, cases, articles, whitepapers and many other resources that provide information on contrast agents, strain imaging and related technology.

Lectures

Testis: Tumour and Inflammation

Testis:  Tumour and Inflammation

Dean Huang, MD

  • Release date: 04/23/2017

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  • Time: 20 mins

Pancreas: Tumour and Inflammation

Pancreas:  Tumour and Inflammation

Mirko D'Onofrio, MD

  • Release date: 04/16/2017

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  • Time: 31 mins

Renal Disease: Transplantation

Renal Disease:  Transplantation

Konrad Friedrich Stock, MD

  • Release date: 04/09/2017

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  • Time: 25 mins

Renal Disease: Technique and Quantification

Renal Disease:  Technique and Quantification

Konrad Friedrich Stock, MD

  • Release date: 03/26/2017

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  • Time: 22 mins

CEUS Non-Liver Guidelines

CEUS Non-Liver Guidelines

Vito Cantisani, MD

  • Release date: 03/19/2017

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  • Time: 22 mins

Cases

Hemangioma of the liver CEUS

  • Author:
  • Carla Serra, MD
  • Category:
  • Abdomen >> Liver & Biliary System

  • Other >> Contrast Agents

Publish Date: 07/16/2012

Patient with a known hyperechoic focal liver lesion, for CEUS study to characterize lesion.

View Case

Liver Metastasis (with CEUS imaging)

  • Author:
  • Olivier Lucidarme, MD, PhD
  • Category:
  • Abdomen >> Liver & Biliary System

  • Other >> Contrast Agents

Publish Date: 07/15/2012

A 58 y.o. male with history of rhino-pharynx cancer treated by radio-chemotherapy presents for CEUS characterization of a known liver lesion.

View Case

Hemangioma of the liver

  • Author:
  • Olivier Lucidarme, MD, PhD
  • Category:
  • Abdomen >> Liver & Biliary System

  • Other >> Contrast Agents

Publish Date: 04/11/2012

The patient is a 53 y.o male smoker with findings of suspicious opacity on a chest plain film.

View Case

Hepatic Cavernous Hemangioma

  • Author:
  • Danilo Sirigu, MD
  • Category:
  • Abdomen >> Liver & Biliary System

  • Other >> Contrast Agents

Publish Date: 12/11/2008

A 39-year-old woman presented with a history of abdominal distention and recurrent abdominal pain.

View Case

A REVIEW OF LOW-INTENSITY ULTRASOUND FOR CANCER THERAPY
ANDREW K. W. WOOD* and CHANDRA M. SEHGALy
*Department Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; and yDepartment of Radiology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

Ultrasound in Med. & Biol., Vol. 41, No. 4, pp. 905–928, 2015

Filename: UMB V41N4 Ca Therapy.pdf

Key Words: Low-intensity ultrasound, Cancer therapy, Sonodynamic therapy, Ultrasound-mediated chemotherapy, Anti-vascular ultrasound, Ultrasound bio-effects, Microbubble contrast agent, Contrast

  • Category:
  • Other >> Contrast Agents

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QUANTIFICATION OF ENHANCEMENT OF RENAL PARENCHYMAL MASSES WITH CONTRAST-ENHANCED ULTRASOUND
YINGYU CAI, LIANFANG DU, FAN LI, JIYING GU, and MIN BAI
Department of Ultrasound, Shanghai First People’s Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China
Ultrasound in Med. & Biol., Vol. 40, No. 7, pp. 1387–1393, 2014
FileName: UMBv40N7_Renal_Masses.pdf
Key Words: Contrast-enhanced ultrasound, Quantitative analysis, Time-intensity curve, Renal cell carcinoma, Diagnosis.

  • Category:
  • Other >> Contrast Agents

  • Abdomen >> Kidneys/Ureters

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GUIDELINES AND GOOD CLINICAL PRACTICE RECOMMENDATIONS FOR CONTRAST ENHANCED ULTRASOUND (CEUS) IN THE LIVER – UPDATE 2012
A WFUMB-EFSUMB INITIATIVE IN COOPERATION WITH REPRESENTATIVES OF AFSUMB, AIUM, ASUM, FLAUS AND ICUS

 Ultrasound in Med. & Biol., Vol. 39, No. 2, pp. 187–210, 2013

 Filename: UMBV39N2

 KeyWords: Diagnosis, Metastases, Hepatocellular carcinoma, Focal nodular hyperplasia, Hemangioma, Microbubble.

 

  • Category:
  • Abdomen >> Liver & Biliary System

  • Other >> Contrast Agents

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QUANTIFICATION OF LEFT VENTRICULAR SIZE AND FUNCTION USING CONTRAST-ENHANCED REAL-TIME 3D IMAGING WITH POWER MODULATION: COMPARISON WITH CARDIAC MRI

PATRICK D. COON, HEIDI POLLARD, KATHLEEN FURLONG, ROBERTO M. LANG, and VICTOR MOR-AVI

Department of Medicine, University of Chicago Medical Center, Chicago, IL

Ultrasound in Med. & Biol., Vol. 38, No. 11, pp. 1853–1858, 2012
FileName: UMB V38N11 Quant LV Size

Key Words: Cardiac, echocardiography, Transthoracic echocardiography, Left ventricle, Ventricular volume, Ejection fraction, Power modulation, Magnetic resonance imaging.

  • Category:
  • Other >> Contrast Agents

  • Cardiac >> Adult

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TRANSCRANIAL ULTRASOUND ANGIOGRAPHY (TUSA): A NEW APPROACH FOR CONTRAST SPECIFIC IMAGING OF INTRACRANIAL ARTERIES THILO HÖLSCHER,* WILKO G. WILKENING,‡ PATRICK D. LYDEN,† and ROBERT F. MATTREY* *Departments of Radiology and †Neurology, University of California, San Diego, CA, USA; and ‡Department of Electrical Engineering, University of Bochum, Bochum, Germany Ultrasound in Med. & Biol., Vol. 31, No. 8, pp. 1001–1006, 2005

  • Category:
  • Brain/Spine >> Adult Brain

  • Other >> Contrast Agents

  • Vascular >> Cerebrovascular

  • Vascular >> Transcranial

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